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Venofer / Products / American Regent Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Deferoxamine chelates iron. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Slowing the infusion rate may alleviate symptoms. This drug is available at a higher level co-pay. Intravenous iron-dextran: therapeutic and experimental possibilities. Modify Therapy/Monitor Closely. Use alternatives if available. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . By clicking send, you acknowledge that you have permission to email the recipient with this information. Share cases and questions with Physicians on Medscape consult. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. If we don't have the calculator you need then tell us the details and we'll make it for you. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Read our. 2. Applies only to oral form of both agents. commonly, these are generic drugs. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. Each mL contains 20 mg of elemental iron. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Applies only to oral form of both agents. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Monitor Closely (1)trientine, iron sucrose. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. All Rights Reserved. Applies only to oral form of both agents. Slow or stop the infusion if adverse reactions occur. Applies only to oral form of both agents. Use Caution/Monitor. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Use Caution/Monitor. To view formulary information first create a list of plans. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Modify Therapy/Monitor Closely. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Applies only to oral form of both agents. Copyright 2021 GlobalRPH - Web Development by. Use Caution/Monitor. Dosage Calculator - [100% Free] - Calculators.io This site complies with the HONcode standard for trust- worthy health information: verify here. Applies only to oral form of both agents. Chandler G, Harchowel J, Macdougall I. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Minor (1)iron sucrose, benazepril. Applies only to oral form of both agents. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Applies only to oral form of both agents. This site contains information for licensed healthcare professionals in the United States. Pediatric Patients (2 Years of Age and Older). vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. The primary endpoint was the proportion of patients with . Applies only to oral form of both agents. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Avoid or Use Alternate Drug. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Avoid or Use Alternate Drug. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Generic name: IRON SUCROSE 20mg in 1mL Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Anemia; 2015: 763576. PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Iron Product. Intravenous iron therapy for patients with anemia Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com Use Caution/Monitor. Each mL contains 20 mg of elemental . Use Caution/Monitor. PDF Treatment Guideline - Gloucestershire Royal Hospital Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Ganzoni AM. Use Caution/Monitor. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Most Venofer may cause clinically significant hypotension. Fatal reactions have followed the test dose of iron dextran injection. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Applies only to oral form of both agents. 2.1 . pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Minor/Significance Unknown. 2010;18(3). Volume of iron product required = 25 mL. Pain, swelling, or redness at the injection site may occur. Applies only to oral form of both agents. Applies only to oral form of both agents. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Iron Deficiency in Heart Failure - Home - American College of Cardiology Venofer must only be administered intravenously either by slow injection or by infusion. This drug is available at the lowest co-pay. Use Caution/Monitor. . 1. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Use Caution/Monitor. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Med J Aust; 193(9):525-32. Manage and view all your plans together even plans in different states. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. FERAHEME vs Venofer (iron sucrose) - Feraheme Minor/Significance Unknown. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Minor/Significance Unknown. Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Iron Sucrose - SlideShare Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Anemias. Applies only to oral form of both agents. David McAuley, Pharm.D. Venofer (Iron Sucrose Injection): Uses, Dosage, Side Effects - RxList (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Either decreases levels of the other by inhibition of GI absorption. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. iron sucrose increases levels of calcium chloride by enhancing GI absorption. For additional Safety Information, please see Full Prescribing Information. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Most Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Before using, check this product visually for particles or discoloration. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. The dosage of iron sucrose is expressed in mg of elemental iron. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Applies only to oral form of both agents. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Iron Deficiency Calculator - MDApp Modify Therapy/Monitor Closely. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Individual plans may vary Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Your doctor will do laboratory tests to monitor your response. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. This calculator will help pinpoint potential causes of anemia based on Applies only to oral form of both agents. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Minor/Significance Unknown. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Use Caution/Monitor. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Applies only to oral form of both agents. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. The elemental iron product used is Iron sucrose 20 mg/mL. Injection site discoloration has been reported following extravasation. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Reference www.medicines.org.uk Background Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Administer on 5 different occasions over a 14 day period. iron sucrose, benazepril. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Applies only to oral form of both agents. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Controlled studies in pregnant women show no evidence of fetal risk. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Separate by at least 4 hours. Avoid or Use Alternate Drug. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Official Journal of the International Society of Nephrology. I. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Crown Rump Length and Nuchal Translucency. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Step 2: Calculation and administration of the maximum individual iron dose(s): . Minor/Significance Unknown. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. . Applies only to oral form of both agents. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Due Date form Ultrasound Report. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Applies only to oral form of both agents. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. The iron formulation choice remains for the clinician to make. Diagnosis and management of iron deficiency anaemia: a clinical update. Applies only to oral form of both agents. Administer Venofer early during the dialysis session (generally within the first hour). Fulminant symptoms include confusion, sensation of passing out, paleness. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. May increase risk of hypotension. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Found in multiple references. 1000 mg. 20 MINUTES. Applies only to oral form of both agents. Venofer must only be administered intravenously either by slow injection or by infusion. Applies only to oral form of both agents. Accessed: 4/12/2011. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Adding plans allows you to compare formulary status to other drugs in the same class. Assure stable intravenous access to avoid extravasation. Treatment of anemia due to iron deficiency. official version of the modified score here. Applies only to oral form of both agents. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Schweiz Med Wochenschr; 100(7):301-3. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Applies only to oral form of both agents. Do not administer Venofer to patients with iron overload. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Iron deficiency anemia is the type of anemia caused by iron depletion. 1982;13(4):309-21. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Methods. Use Caution/Monitor. Deferasirox chelates iron. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Applies only to oral form of both agents. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. No additional iron to replenish stores. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Applies only to oral form of both agents. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. Applies only to oral form of both agents. Compare formulary status to other drugs in the same class. Written by ASHP. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Dosing and Infusion Rates - PRIVIGEN Applies only to oral form of both agents. Medicinal forms Included in the iron dextran package insert. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Deferoxamine chelates iron. Iron Sucrose (Ferogen): Indications, Dosage, Administration - Medcrine Calculosaurus | Ferinject dose calculator

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